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Immunovir is available
by prescription outside of the U.S. Immunovir's active ingredient is isoprinosine,
which is available as Isoprinosine Pranobex and Inosine.
Immnovir and Isoprinosine may be ordered from the following providers.
Newport
Pharmaceuticals
Markets both Imunovir and Isoprinosine; may be ordered by US residents
without prescription
Dublin, Ireland
Ph. 353-1-890-3011
Fax 353-1-890-3016
info@newport-pharma.com
Pharmacia
Sucre, S.A.
San Jose, Costa Rica
Ph. 506-00-233-6380, 506-223-1715
Fax 506-00-233-9869
newportp@sol.racsa.co.cr
There is no area/city
code for Costa Rica so you may not need to dial the 00
Life
Extension Foundation - Inosine
1100 West Commercial Blvd
Fort Lauderdale, FL 33309
800-544-4440
Take the same quantity
of Inosine as Immunovir/Isoprinosine. If you will be buying other products
from LEF, it may well be worth it to become a member in order to obtain
member discounts.
About
Isoprinosine (Inosine)
What is Isoprinosine?
Isoprinosine is a nucleoside, one of the basic compounds comprising
cells. It is a precursor to adenosine, an important energy molecule, and
plays many supportive roles in the body, including releasing insulin,
facilitating the use of carbohydrate by the heart, and, potentially, participating
in oxygen metabolism and protein synthesis. Based upon anecdotal reports
by Russian and Eastern European athletes, inosine has been investigated
for ergogenic (exercise boosting) effects. Results of controlled studies
have been disappointing, however, suggesting that inosine does not improve
athletic performance and may even impair it. [1, 2It is used as an immune
stimulator for cancer, herpes, and AIDS.
Where is it found?
Isoprinosine is found in Brewer's yeast and organ meats. It is also
available as a supplement. ]. It is marketed as a drug in many nations
(but not yet in the United States). Isoprinosine is marketed under other
names, including Isoprinosine Pranobex and Inosine.
Who is likely to
be deficient?
Isoprinosine is not an essential nutrient, so deficiencies
do not occur.
How much is usually
taken?
Although a common amount of Isoprinosine taken by athletes
is 5,000-6,000 mg per day, little scientific evidence supports the use
of this supplement at any level.
Are there any side
effects or interactions?
No side effects have been reported with the use of Isoprinosine for
two to five days in the limited research available. However, unused Isoprinosine
is converted by the body to uric acid, which may be hazardous to people
at risk for gout.
Before Using
Tell your doctor if you:
-
are taking medicine
or are allergic to any medicine (prescription or over-the-counter
(OTC) or dietary supplement)
-
are pregnant
or plan to become pregnant while using this medicine
-
are breastfeeding
-
have any other
health problems, such as high blood pressure or heart or blood vessel
disease
Dosage
There are many doses for this medicine. Isoprinosine should only be
used under direct supervision of your health care professional, please
consult them for proper dosing. (See special dosing notes for CFS and
AIDS below.)
To store this medicine
Keep all medicine locked up and away from children. Store medicine
away from heat and direct light. Do not store your medicine in the bathroom,
near the kitchen sink, or in other damp places. Heat or moisture may cause
the medicine to break down and not work the way it should work. Throw
away medicine that is out of date or that you do not need. Never share
your medicine with others.
Warnings
Before taking Isoprinosine, tell your doctor if you are pregnant or
breastfeeding. Those with gout or a predisposition to develop gout should
not use Isoprinosine.
Side Effects
Stop taking your medicine right away and talk to your doctor if you
have any of the following side effects. Your medicine may be causing these
symptoms which may mean you are allergic to it.
-
Breathing problems
or tightness in your throat or chest
-
Chest pain
-
Skin hives, rash,
or itchy or swollen skin
-
Other Possible
Side Effects: This medicine may also cause other side effects. Tell
your doctor if you have side effects that you think are caused by
this medicine.
References
1. Starling RD, Trappe TA, Short KR, et al. Effect of inosine
supplementation on aerobic and anaerobic cycling performance. Med Sci
Sports Ex 1996;28(9):1193-98.
2. Williams MH, Kreider
RB, Hunter DW, et al. Effect of inosine supplementation on 3-mile treadmill
run performance and VO2 peak. Med Sci Sports Exerc 1990 Aug;22(4):517-22.
Isoprinosine/Imunovir
(Inosine) Dosage
The following information on dosing is from The
Body's page on isoprinosine, reiterating some of the dosages referenced
in the research on isoprinosine for HIV/AIDS:
There
is no way to know what the proper dose is. However the clinical studies
thus far have examined between 1 - 4 grams per day. The Danish study
used 1 gram three times a day. The tablets we distribute are 500 MG
each. To take the doses used in the studies, you would take between
2 and 8 tablets every day. To our knowledge, only one study has evaluated
how isoprinosine is absorbed and excreted in humans. This study demonstrated
that isoprinosine doesn't stay in the body very long. To keep consistent
levels of isoprinosine in the body would require fairly frequent oral
doses, three or more times a day. Taking isoprinosine as an injection
or an enema may deliver initially higher doses into the blood, but the
body eliminates this isoprinosine just as quickly. We don't know whether
the body requires consistent levels of an immune modulator in order
to respond to it, but if it does, oral dosing is the easiest way to
achieve this.
CFIDS doctor Paul Cheney
MD recommends the following dosing and frequency of Immunovir for Th1/Th2
dysregulation:
Month 1:
Week One, take
6 tablets a day, Monday through Friday, and none on the weekend.
Week Two, take 2 tablets a day, Monday through Friday, and none on
the weekend.
Week Three, repeat Week One.
Week Four, repeat Week two.
Month 2: Repeat
Month 1.
Month 3: Take
the month off - do not take any isoprinosine (Immunovir) during the
third month.
Month 4: Repeat
Month 1.
Month 5: Repeat
Month 1.
Month 6: Take
the month off.
According to Cheney,
this medicine works best when you use this "pulsing" treatment
of two months on, one month off, and the different amounts each week during
the months that you are taking it, rather than taking it at the same dose
all through the "on" months, or at the same dose continuously
for six months. It may be that all immune modulators work like this, working
better and for longer periods of time when they are pulsed.
CFIDS doctor Byron
Hyde MD, has a preliminary report on isoprinosine at his Nightingale
Foundation site.
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