Research

Gordon Medical has been actively doing research into Chronic Fatigue Syndrome, MCS, and Lyme Disease since 2005. We are now also partnering with researchers at Stanford University, along with several groups working to improve collecting and processing patient history and outcome data. In 2014 we established Science in Service of Humanity to be our research arm, and in 2016 we founded the Gordon Medical Research Center, a non-profit fundraising corporation that would allow tax deductible donations to support our research.

See the Team at GMRC

Gordon Medical Research Center

Funding Research Into Poorly Understood Chronic Illness

The opening of the Gordon Medical Research Center is a critical element in developing funding for the research into the complex illnesses we focus on. Your donation will make possible further research into metabolomics and mitochondrial function and their impact on health and illness. Illnesses potentially caused by mitochondrial dysfunction will ultimately affect over 50% of the people born today. These diseases include autoimmune diseases, autism, Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS), Post-Traumatic Stress Disorder (PTSD), Gulf War Illness, diabetes, heart disease, certain mental health disorders, and cancer.

See the Team at SISOH

Science in Service of Humanity

Science in Service of Humanity (SISOH) is a research organization focused on poorly understood and defined illness such as CFS/ME, chronic Lyme Disease, Fibromyalgia, Autism, and Multiple Chemical Sensitivity.

We have been involved in the Metabolomics research that resulted in the published paper, “Metabolic features of chronic fatigue syndrome“. We are continuing our reserach into metablomics in the new study, Analyzing Individual Metabolomics Study (AIMS). You can find out more about the research, and sign up to participate on the SISOH website.

Published Study - Metabolic features of chronic fatigue syndrome

Metabolomics ResearchOur Metabolomics study on Chronic Fatigue Syndrome was published August 2016 in the Proceedings of the National Academay of Sciences (PNAS), one of the most prestigious medical journals in the US and the world. This ground breaking study is changing the way chronic illness, and Chronic Fatigue Syndrome in particular will be understood and treated.

Chronic fatigue syndrome is a multisystem disease that causes long-term pain and disability. It is difficult to diagnose because of its protean symptoms and the lack of a diagnostic laboratory test. We report that targeted, broad-spectrum metabolomics of plasma not only revealed a characteristic chemical signature but also revealed an unexpected underlying biology. Metabolomics showed that chronic fatigue syndrome is a highly concerted hypometabolic response to environmental stress that traces to mitochondria and was similar to the classically studied developmental state of dauer. This discovery opens a fresh path for the rational development of new therapeutics and identifies metabolomics as a powerful tool to identify the chemical differences that contribute to health and disease.

Read the full study

Metabolomics Q&A for CFS v6

What They Are Saying About
Metabolic features of chronic fatigue syndrome
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Metabolic features of chronic fatigue syndrome - Chronic fatigue syndrome may be a human version of ‘hibernation’ - A new study raises the extraordinary possibility that humans may be able to put themselves into a kind of hibernation state as well — but in a way that hurts us rather than helps us.

Ariana Eunjung Cha - Washington Post Read full article
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Metabolic features of chronic fatigue syndrome - NAVIAUX’S METABOLISM PAPER IS ABOUT AS BIG AS YOU THINK - For those who are wondering at the results and their implications, Naviaux’s study in a nutshell states that the cells of ME patients are in a sort of protective hibernation, limiting their consumption of resources and engaging in a hypometabolic state as a response to infection or other stressors. By examining patients’ metabolites in detail, it was found that this degree of protective hibernation correlates directly to clinical severity. Naviaux also posits that cells in ME/CFS are cells under enormous stress, for which they create a series of defenses, metaphorically installing a superior lock and alarm system and hiding all the valuables. However, some pathogens know the code to get in, and when the resources are hidden, the host can’t use them, either. Both of these aspects of this mode of cellular defense have profound implications for symptomology.

Jaime Seltzer - ME Action Read full article