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New Study Finds Lyme Bacteria Survive a 28-day Course of Antibiotics When Treated Four Months After Infection by Tick Bite

Risk of Tick Bites in Tall Grass

Risk of Tick Bites in Tall Grass

All subjects treated with antibiotics were found to have some level of infection 7–12 months post treatment.

Despite testing negative by antibody tests for Lyme disease, two of 10 subjects were still infected with Lyme bacteria in heart and bladder.

Lyme bacteria which persist are still viable.

Portola Valley, California, Dec. 13, 2017 — Bay Area Lyme Foundation, a leading sponsor of Lyme disease research in the US, today announced results of two papers published in the peer-reviewed journals PLOS ONE (read full paper) and American Journal of Pathology (read full paper), that seem to support claims of lingering symptoms reported by many patients who have already received antibiotic treatment for the disease.

Based on a single, extensive study of Lyme disease designed by Tulane University researchers, the study employed multiple methods to evaluate the presence of Borrelia burgdorferi spirochetes, the bacteria that cause Lyme disease, before and after antibiotic treatment in primates. The study also measured the antibody immune response to the bacteria both pre- and post- treatment, as this is how current diagnostics typically evaluate Lyme disease in humans.

The data show that living B. burgdorferi spirochetes were found in ticks that fed upon the primates and in multiple organs after treatment with 28 days of oral doxycycline. The results also indicated that the immune response to the bacteria varied widely in both treated and untreated subjects.

“It is apparent from these data that B. burgdorferi bacteria, which have had time to adapt to their host, have the ability to escape immune recognition, tolerate the antibiotic doxycycline and invade vital organs such as the brain and heart,” said lead author Monica Embers, PhD, assistant professor of microbiology and immunology at Tulane University School of Medicine.

“In this study, we were able to observe the existence of microscopic disease and low numbers of bacteria, which would be difficult to see in humans but could possibly be the cause of the variable and nonspecific symptoms that are characteristic of post-treatment Lyme disease syndrome. Although current antibiotic regimens may cure most patients who are treated early, if the infection is allowed to progress, the 28-day treatment may be insufficient, based on these findings,” Embers said.

The findings also demonstrated:

  • All subjects treated with antibiotics were found to have some level of infection 7-12 months post treatment.
  • Despite testing negative by antibody tests for Lyme disease, two of 10 subjects were still infected with Lyme bacteria in heart and bladder.
  • Lyme bacteria which persist are still viable.

To better elucidate previous animal studies demonstrating that some B. burgdorferi bacteria survive antibiotics, the study explored Lyme disease infection in rhesus macaque primates treated with antibiotics and a control group who were also infected but not treated. This species has been shown to demonstrate a progression of Lyme disease most similar to humans, particularly related to erythema migrans, carditis, arthritis, and neuropathy of the peripheral and central nervous systems.

“Clearly, some medical practices governing diagnosis and treatment of Lyme disease should be reconsidered in light of this study. This study shows that we must reevaluate the current paradigm of antibody response tests for diagnosis and move away from the one size fits all approach to Lyme treatment,” said Wendy Adams, Research Grant Director, Bay Area Lyme Foundation. “Every day, patients with Lyme disease are told their symptoms cannot be caused by Lyme, because they test negative on antibody tests or because they have received a single course of antibiotics. More research and funding are imperative.”

In the study, ticks carrying B. burgdorferi spirochetes fed on ten primates. Four months post infection, half of the primates (five) received the antibiotic doxycycline orally for 28 days at a proportional dose to that used in human treatment. Five subjects were treated with placebo and all ten were evaluated by more than five different diagnostic methods to characterize any remaining infection. The researchers used several important techniques, including xenodiagnoses, to determine if the spirochete bacteria persisted.

The results show:

Few subjects displayed a rash. Although all subjects were infected, only one of the 10 displayed a rash with central clearing, the classical “bulls-eye” rash. The subject that developed this rash, interestingly, never mounted an immune response to five borrelia antigens throughout the study period, prior to and following treatment.

Organs may be infected even if antibody tests are negative. One subject which tested negative for B. burgdorferi by skin biopsy cultures, PCR and in vivo cultures, was found to have B. burgdorferi infecting the heart. Another untreated subject, who was ultimately shown to have residual Lyme bacteria in the bladder, showed a decrease in immune response over the course of infection, with a negative xenodiagnosis test in the late stage, which would signal that the animal self-cured.

Intact spirochetes were found in three of five treated and four of five untreated subjects based on xenodiagnosis results 12 months after the tick bite.

Immune responses to B. burgdorferi varied greatly post-treatment, with one subjects antibody levels dropping to pre-bite levels for three antigens while another subject experienced elevated antibodies for the same antigens throughout the study period. This is significant because it demonstrates that subjects infected with the same strain of B. burgdorferi may have different immune responses to the same antigen. And, because humans, like primates, are genetically diverse, it underscores that testing antibody responses may be inherently unreliable as a singular diagnostic modality for Lyme disease.

Widespread and variable microscopic disease was observed in all infected subjects, despite antibiotic treatment. Compared to uninfected subjects of the same age, infected subjects in this study (treated and untreated) demonstrated Inflammation in and around the heart, in skeletal muscles, joints, and the protective sheath that covers the brain, and near peripheral nerves.
Rare, but intact B. burgdorferi spirochetes were found in the tissues of both the treated and untreated subjects. In two subjects treated with doxycycline, multiple Lyme bacteria were observed in the brain tissue. Others organs in which the spirochetes were observed included the heart, joints, bladder, skeletal muscle and adjacent to peripheral nerves.

Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding

Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques

About Lyme disease
One of the most common infectious diseases in the country, Lyme disease is a potentially disabling infection caused by bacteria transmitted through the bite of an infected tick to people and pets. If caught early, most cases of Lyme disease can be effectively treated, but it is commonly misdiagnosed due to lack of awareness and unreliable diagnostic tests. There are about 329,000 new cases of Lyme disease each year, according to statistics released in 2015 by the CDC. As a result of the difficulty in diagnosing and treating Lyme disease, as many as one million Americans may be suffering from the impact of its debilitating long-term symptoms and complications, according to Bay Area Lyme Foundation estimates.

About Bay Area Lyme Foundation
Bay Area Lyme Foundation, a national organization committed to making Lyme disease easy to diagnose and simple to cure, is the leading public foundation sponsor of innovative Lyme disease research in the US. A 501c3 non-profit organization based in Silicon Valley, Bay Area Lyme collaborates with world-class scientists and institutions to accelerate medical breakthroughs for Lyme disease. It is also dedicated to providing reliable, fact-based information so that prevention and the importance of early treatment are common knowledge. A pivotal donation from The Laure L STEM Fund covers all overhead costs and allows for 100% of all donor contributions to Bay Area Lyme Foundation to go directly to research and prevention programs. For more information about Lyme disease or to get involved, visit www.bayarealyme.org or call us at 650-530-2439.

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UNREST – Watch Free on PBS Website

 

15 great documentaries are in contention for an Oscar but only one was directed from bed. See how Jen Brea, with creativity, tenacity and tech, made the breakthrough doc UNREST.  Follow filmmaker Jennifer Brea’s struggle with Chronic Fatigue Syndrome and meet others coping with this often-devastating and little-understood condition in this intimate documentary.

Watch Free on PBS website.

Not in the US? Here are all the ways to watch: http://unrest.film/watch

#UnrestPBS #Spoonie

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UNREST – Independent Film about CFS/ME Tonight on PBS – in the running for an Oscar!

 

15 great documentaries are in contention for an Oscar but only one was directed from bed. See how Jen Brea, with creativity, tenacity and tech, made the breakthrough doc UNREST *tonight*, Jan 8th, on PBS. http://www.pbs.org/independentlens/tv-schedule/#schedule-local

To watch locally in the San Francisco Bay Area:

Unrest

Follow filmmaker Jennifer Brea’s struggle with Chronic Fatigue Syndrome and meet others coping with this often-devastating and little-understood condition in this intimate documentary.

UPCOMING BROADCASTS:

  • KQED 9: Mon, Jan 8, 2018 — 10:00pm
  • KQED 9: Tue, Jan 9, 2018 — 4:00am
  • KQED World: Wed, Jan 10, 2018 — 5:30pm
  • KQED World: Thu, Jan 11, 2018 — 6:30am
  • KQED World: Thu, Jan 11, 2018 — 12:30pm
  • KQED World: Sat, Jan 13, 2018 — 9:00am

#UnrestPBS #Spoonie

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Happy Holidays From GMA!

Happy Holidays GMA 2017
From all of us, to all of you! To those who made it through the year, we wish you joy and love and health in the new one. To those who have suffered losses, our hearts are with you. GMA will continue to do all that is possible to serve it’s patients and the larger community in 2018, hoping for recovery in body, home, and friends and family.

Salut! * Sláinte! * 乾杯! * Skål! * Proost! * நல் ஆரோக்கியம் பெருக * Saúde! * Cheers! * शुभमस्तु  * Santé! * Prost!  * གཟུགས་པོ་བདེ་ཐང་། *  Le’tenachin!  * Ahóá!  * Бу́дем здоро́вы!  * L’Chaim!

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Interview with Michelle Perro, MD – What’s Making Our Children Sick?

Michelle Perro, MDAccording to the CDC, one out of two children in our country now has a chronic disorder. There is an epidemic of Autism Spectrum Disorder in our country, with one in 43 boys being affected, and one in 68 children overall. In addition, one in five children is obese, and one in eight has asthma (one in six African-American children). Children are also showing record levels of autoimmune disorders. Children with chronic stomach-ache or constipation are now so common that parents don’t even think of it as a problem any more. Learning challenges such as ADD and ADHD have become commonplace household names.

Want to find out what you can do to help our children? Michelle Perro, MD, has been researching and working clinically with children now for 37 years, and she has some ideas for you. Dr. Perro has been a tireless advocate concerning the role of GM food and their associated pesticides and their effect on children’s health. Listen to her interview in the podcast linked below, and order her new book, “What’s Making Our Children Sick?“, coming January 2018.
What's Making Our Children Sick?

Carol Grieve, of Food Integrity Now, interviews Michelle Perro, MD

PODCAST: PLAY IN NEW WINDOW | DOWNLOAD (DURATION: 49:21 — 22.6MB)

Find out more about “What’s Making Our Children Sick?”
Pre-order the book!

 

Chronic disorders among American children have reached epidemic levels. Hundreds of thousands of parents are desperately seeking solutions to their children’s declining health. Food Integrity Now spoke with Dr. Michelle Perro, Pediatrician and co-author of What’s Making Our Children Sick? How Industrial Food is Causing an Epidemic of Chronic Illness and What Parents (and Doctors) Can Do About It. This book is a radical rethinking of the relationships between our children’s food, medicine and health in this timeframe. Dr. Perro offers first-hand and well-researched information about what is making our children sick and provides solutions that could help turn around this epidemic. Her information is both practical and scientific and is a must read for parents, doctors or anyone who wants to improve their health and the health of their children.

Food Integrity Now is funded by your donations, if you can please donate here!

Carol Grieve of Food Integrity Now

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New Findings: Non-GMO Eaters Recover from Obesity, Anxiety, and Chronic Diseases

If you’ve been wondering if you really need to switch to non-GMO foods, a new peer-reviewed article may change your mind—and your life. View a powerful and informative video interview of Michelle Perro, MD, a top pediatrician who witnesses in her practice every day the same type of health improvements reported in the survey.

*The links mentioned in the video are listed below. You can also see them on this page, and sign up there to get advance notice about the new video that will be premiered soon, as well as the ebook offered. 

*Find out more about Michelle Perro, MD and her book “What’s Making Our Children Sick?” due out in January 2018.The book is available for pre-order now!

A new article, “Survey Reports Improved Health After Avoiding Genetically Modified Foods,” focuses on a survey conducted by the Institute for Responsible Technology (IRT) of more than 3250 people who switched to a largely non-GMO diet and reported improvements in 28 health conditions. An astonishing 85% of respondents reported improvements in their “digestive problems,” the ailment most commonly cited. Of these respondents, 80% said their digestive issues were “significantly improved”, “nearly gone”, or “completely recovered”.

Remarkably, at least half the respondents also reported recovery from fatigue, obesity, brain fog, food allergies, and anxiety or depression. Access the article with the complete list of conditions that improved.

What is it about GMOs that may be damaging our health? The article, peer-reviewed and published in the International Journal of Human Nutrition and Functional Medicine, lays out the known side effects, ranging from increased allergens and toxins in the food to high residues of Roundup® herbicide. (see more about the dangers of Roundup.) Most GMOs are designed to withstand heavy doses of Roundup, which, according to the World Health Organization, is a known carcinogen. Jeffrey M. Smith, the article’s author, cites evidence of many other serious health dangers of this popular herbicide as well as of GMOs.

Simply eating non-GMO isn’t always sufficient to protect your help, says Smith, since many non-GMO crops are also doused with Roundup just before harvest.

Find out how to protect yourself and your family. View either the easy-to-read summary or the scientific, peer-reviewed article itself.

Make sure to watch or record the Jeffrey Smith interview on The Doctors on Wednesday, October 8- we need high numbers to let the media networks know that glyphosate harm is a MAINSTREAM issue.

Notice courtesy of Moms across America

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Monsanto’s Roundup: Could the foods you eat or the weed killer you use give you cancer?

Don’t miss Jeffrey Smith and others, on The Doctors TV Show this Wednesday. The subject is “Monsanto’s Roundup: Could the foods you eat or the weed killer you use give you cancer?”

The doctors

Click here to find out when it’s on in your area.

See a 30 second clip.  Warning: volume on clip is high. 

On Wednesday, November 8th, the national TV show The Doctors will spend an entire hour-long episode discussing the controversy around Monsanto and its herbicide, Roundup.

Could the foods you eat or the weed killer you use give you cancer? In a Doctors’ exclusive, they discuss a lawsuit claiming the most widely-used herbicide in the world, glyphosate, led to Non-Hodgkin Lymphoma in an alleged victim. Hear from the attorney in the case and the widow of a farmer who claims agricultural chemicals cut his life short. Find out why chemical companies say they stand by the safety of their product. The Doctors help you sort through the science and offer practical solutions starting in the grocery store!

The show’s guests include:
Jeffrey Smith, bestselling author of Seeds of Deception and Genetic Roulette, leading spokesperson on the health dangers of GMOs, and an expert on the ways Monsanto manipulates science to cover-up health impacts.

Brent Wisner, a lead attorney in federal litigation against Monsanto, in which thousands claim that exposure to Roundup caused non-Hodgkin lymphoma. The litigation forced Monsanto to release documents, emails, and texts, which, according to Wisner’s firm, “tell an alarming story of ghostwriting, scientific manipulation, collusion with the Environmental Protection Agency (EPA), and previously undisclosed information about how the human body absorbs glyphosate [the main ingredient in Roundup].”

Teri McCall, a plaintiff in the lawsuit. Teri’s husband Jack, accompanied by the family dog Duke, regularly sprayed Roundup around their farm. Jack died of Non-Hodgkin’s lymphoma, while Duke died of lymphoma.

Jeffrey Smith, the founder of the Institute for Responsible Technology, first appeared on The Doctors in 2015, after the World Health Organization’s expert committee made the determination that Roundup’s active ingredient glyphosate probably causes cancer. In that show, he faced off against Donna Farmer, Monsanto’s senior toxicologist, who dismissed the herbicide’s link to cancer saying, “I mean this very honestly, I am extremely highly confident in this product.” But according to Monsanto’s secret documents, says Smith, Farmer was far from confident in private.

To find the time and station in your city, go to http://photos.thedoctorstv.com/when-its-on/.

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The Role of Dysbiosis and Chronic Infections on Cognitive and Psychological Health – Nafysa Parpia

This podcast is part of the Collective Insights Podcast series through the Neurohacker Collective. In this podcast, Daniel Schmachtenberger interviews Nafysa Parpia, ND about the role of the gut in illness and health. You can see a full transcript of the podcast on the Neurohacker webpage. You can also listen to the full podcast series by subscribing.

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“Functional and integrative medicine that is heart centered guides how I treat my patients with complex chronic illness. Biochemical imbalances, epigenetic expression, toxin exposure, microbial exposure and emotional imbalance are often key in unraveling the mystery of and treating chronic illness. Each of these aspects is different for each patient. Thus, with compassionate listening and cutting edge laboratory tests, I can create treatment plans that are highly individualistic and healing.” – Nafysa Parpia, ND

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Cosmetic Botox® Now Available at GMA

Nafysa Parpia injecting Botox

Nafysa Parpia, ND, injecting Botox into a patient.

Botulinum Toxin Type A (Botox®), produced by Allergan is a medication that is used to treat dynamic wrinkles such as crow’s feet, forehead lines, and frown lines. Botulinum Toxin A can also be used on the lower face to treat the muscles that cause tiny lines around the mouth, the “sad lines” at the corners of the mouth, as well as the aging appearance of the neck. Botulinum Toxin A Cosmetic works by relaxing the facial muscles, creating a smoother more refreshed appearance.

Nafysa Parpia, N.D. is an independent practitioner working out of both the Santa Rosa and the Marin offices of Gordon Medical. In addition to utilizing a range of injection therapies such as neural therapy, prolozone and prolotherapy, she has added the use of cosmetic Botox® to the treatments she offers. Dr. Parpia is trained to analyze your individual facial anatomy and then formulate the Botulinum Toxin A dose that will give you the best cosmetic enhancement and longevity.

See more information about Botulinum Toxin Type A (Botox®)

See all GMA injection therapies

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Jay Callender, MS TCM, L.Ac., Dipl. OM brings Acupuncture and Traditional Chinese Medicine to GMA

Placing Needles

Gordon Medical welcomes Jay Callender to our offices! Jay has years of experience supporting patients with chronic illnesses which will stand him in good stead at this difficult time, as our patients find the need for support even more important than usual. Call the office to make an appointment to see Jay now at (707) 575-5180.

Independent Practitioner
Licensed Acupuncturist
Diplomate of Oriental Medicine

“Balance in all things is a major component of our health and happiness. If there is balance between our external and internal environments health will occur naturally. This balance is not fixed but is constantly shifting, requiring a certain level of attentiveness from us. Doing just enough to achieve balance is all that is required. Thus, doing less can be more.

Balance should also exist between physician and patient. When the communication is clear, honest, and compassionate, the process of healing is enhanced.”

Jay Callender, LAc

Jay  has been studying Asian culture, martial arts systems, and healing practices since the early 1970’s, and is a respected teacher, lecturer, and clinical practitioner. He was born in Newark, New Jersey, shortly after which he spent his early years living and being educated in abroad. [Read more…]