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A-FNG Part Two: Chronic Mold Infections and Lyme Disease.

You will find detailed information on the following pages. This information is provided for educational purposes only, and is not intended to diagnose or treat an individual. Please understand that Dr. Anderson and Gordon Medical cannot prescribe or recommend treatment to patients they have not seen.

Wayne Anderson ND image

Wayne Anderson ND combines Functional and Integrative Medicine disciplines with the best of conventional medicine.

By Wayne Anderson ND

See Part One

Patients with Chronic Lyme disease can also have chronic fungal infections. Chronic immune suppressed Lyme disease patients have multiple opportunistic infections that can include mold and yeast infections. Knowing when to treat Borrelia, Babesia, Bartonella, Ehrlichia, Mycoplasma or chronic mold infections can be difficult.

For most of our patients Borrelia and the co-infections need to be treated first, but not always. For some patients the fungal infection is the primary pathogen. Factors that determine an individual’s dominant pathogen will be dependent on the patient’s genetics susceptibility, extent or number of exposures and organism pathogenicity. For others their chronic mold infection will be secondary to Lyme and the co-infection. When the immune system prioritizes a fungal infection, as its dominant pathogen there will be a specific symptom picture.

Symptom Review for Chronic Fungal Infections.

Differential Diagnosis:

Signs and symptoms of mycosis can be local and/or systemic. They often simultaneously affect multiple organ systems and defy conventional diagnosis and lab test. Treatment protocols are often ineffective.

Superficial symptoms:

Chronic sinusitis, stuffy nose, otitis media and external, sore throat, cough, asthma, shortness of breath (SOB), esophogitis, nausea, belching, abdominal bloating, gas, irritabel bowel syndrome (IBS), anal itching, vaginosis, vaginitis, cystitis, frequent and urgent urination, skin lesions, irritations and itching, opacity of the nails.

Systemic symptoms:

Chronic fatigue is common. Significant depression with sleep disturbance, anxiety states and mood swings. Mycotoxin related neuropathy with bilateral numbness and tingling, which does not follow dermatome nerve distribution. Behavioral disorders, difficulty learning, autism, memory and concentration dysfunction, headaches, must be considered related to these pathogens.

Considering Fungal the dominant pathogen.

  • Think mold when a patient has inflammation of the mucous membrane and neurological symptoms.
  • The patient’s mucous membrane symptoms often involve the sinuses, sore throat, asthma, allergies, IBS with gas and bloating, vaginitis, urgency to urinate.
  • These areas are itchy and irritated.
  • These inflamed areas are worse in the winter or during the wet season.
  • Symptoms are worse with mold exposure.
  • When the mood is dark and depressed.
  • Can have disruptive effects on behavior, attention, and learning.
  • Pain is usually mild and bilateral.

Treatment can be broken down into three categories

  1. Supporting the immune system.
  2. Killing the dominant pathogen.
  3. Detoxification from the cell through the liver, kidney, lymphatic’s and bowel.And then . . .
  4. Functional support, rehabilitation, or rejuvenation when needed.

These treatment approaches can be applied to patients with chronic fungal infections:

  • Treating the overgrowth of mold on the mucous membrane.
  • Limiting exposure to external mold.
  • Binding the mold in the gut with neurotoxin binding agents.
  • Stabilize the overactive immune response to the fungal organisms.
  • Helping the cells eliminate the lipophillic fungal toxins.

Case Studies involving patients with Borrelia, co-infection constellations and chronic fungal infections.

Patient Demographics include:

  • Positive IGenex Western Blot IgM and/or IgG for Borrelai burgdorferi.
  • Patients with Lab Corp CD- 57 results range from 45 to 90.
  • C4a> 3000
  • HLA-DRB typing
  • Between the ages of 25 to 45.
  • Known tick bite, in endemic area.
  • Without complicating co-morbidities.
  • No post exert fatigue
  • No prescription medication before treatment.
  • Patients that have responded to co-infection treatment.

Patient No. 1:

Previously healthy 34-year-old female with progressively worsening symptoms over the last 5 years.

Past Medical History:

Chronic allergies as a child with mild episodic asthma, dysthymic depression and IBS.

Initial interview:

Chief Complaint:

Unstable mood (both anxious and depressed), cognitive and memory processing problems, fatigue, difficulty falling and staying asleep.

Subjective (Patient’s reports):

Dizziness, SOB, occipital head pain. Easily overwhelmed, increased problems at work due to difficulty multitasking.

Review of Systems (ROS) upon questioning patient:

Head pressure, night sweats, temperature intolerance, chills, minor low back pain, and mild bilateral neuropathy in hands. Intermittent diarrhea with multiple food allergies, gas and bloating. Energy 4/10. SOB, similar to air hunger.

Assessment:

Probable Babesia Like Organism with Lyme under that and a possible mold component.

Treatment course:

10 weeks of A-BAB progressive dosing as tolerated to 25 drops 2x per day followed by Mepron and Zithromax for 6 weeks.

Response after 4 months:

Improved symptoms:

Memory and cognitive processing, dizziness, night sweats, temperature intolerance, chills, anxiety states.

Persisting or unresolved Symptom Picture:

Mild headache, moderate depression, and abdominal gas with bloating.

Worsening Symptoms:

Back, neck and shoulder pain, moderate neuropathy hands Left worse than Right, moderate to severe bilateral leg muscle aching, and significant fatigue (energy 2/10).

Second Assessment:

Babesia Symptom Picture 70% improvement in 4 months of Babesia treatment. Borrelia symptom picture more dominant consider Borrelia treatment.
In the last 5 months, during Babesia treatment her Lab Corp CD 57 dropped from 68 to 31.

Second Treatment course:

Rocephin IV 2 gm bid, 4 days on 3 off, with Doxycycline 100 mg, 2 tablets 2x per day, and Actigal.

Response:

Resolved symptoms after 2 months:

Back, neck, and shoulders pain.
No headache, pressure or occipital head pain.

Improved but persistent symptoms:

Mild neuropathy hands improved from moderate and now equal bilateral.
Mild bilateral muscle ache.
Sleep improved but still restless.
Fatigue (energy 4/10).

Worsening symptoms:

SOB, asthma-like, severe abdominal bloating and gas,
Dark mood with flat affect.
Sinus congestion and mild sore throat.

Third Assessment:

Inflammation more superficial with much of the mucous membranes involved. Neurological symptoms much improved, with only remaining neuropathy in hands now bilateral. Lyme symptom picture improved with a dominant mold presentation now.

Question:

Is the abdominal bloating and gas related to the mold symptom picture, or a result of the antibiotics, or both?

Third Treatment Course over 3 months on A-FNG:

With the probable dominant mold symptom picture this patient used A-FNG. She was sensitive to small dosages starting at 4 drops 2x/day. Over the first 6 weeks she had disruption in her mood, energy and sleep on one drop increases every 5 to 10 days. After reaching 12 drops she was able to increase more quickly with less aggravation in her symptoms. After 3 months she was at 20 drops 2x per day with resolved depression, SOB, neuropathy, and muscle aches. An increase of 5 drops to 25 drops 2x per day was uneventful.
Even with improvement of Borrelia symptoms this patient used A-Lyme Complex for one month with A-FNG. This was to continue unloading the Lyme without additional adverse effect on the gut. A-L Complex was stopped after 4 weeks without relapse in improved symptoms.

Patient No. 2:

45-year-old male transferring into my practice on antibiotic treatment. He has been treated for Lyme with multiple antibiotics for 2 years. His current regiment was Bicillin LA 1.2 million units’ 2x per week with Zithromax 500 mg daily and Flagyl 250 mg 2x per day pulsed dose for the last three months. He had little change in his symptom over the last 6 months.

Chief Complaint:

Restless, irritable, difficulty sleeping and low energy.

Subjective (Patient’s reports):

Diarrhea, gas and bloating. Anal itch, hemorrhoids and acid reflex. Any food induces diarrhea.
Moderate to severe depression that is worse when abdominal symptoms are aggravated.
Generalized muscle aching worse in the back, neck and shoulders.
Large muscle Fasiculations random and fleeting, worse in the torso, thighs and shoulders.
Pain in the whole hands and joints bilateral.

Review of Systems (ROS) upon questioning patient:

Sinus congestion, difficulty breathing through stuffy nose.
Plugged Eustachian tubes with difficulty hearing.
Mild sore throat.
Mild head ache
Reactive to mold exposure, feels dizzy, spacey with headache within minutes of contact.

Assessment:

How many of his symptoms are still related to Lyme and the co-infection vs. chronic mold infections? What parts of his symptoms are related to drug side effects, toxicity response vs. Herx response?

Treatment Course:

Patient stopped all antibiotic for a trial period to evaluate response.
Patient started A-FNG and responded to 6 drops 2x per day and increased to 15 drops 2x per day in the first 6 weeks. On return visit his symptoms were 70% better. He continued to improve as he increased the A-FNG to 25 drops 2x per day.
His treatment course concluded with detox and drainage and gut rebuilding and reinocultation.
All neurological symptoms resolved within three months.

Comments

  1. Hi! I’m really interested in this article. I actually was doing some research on “biotoxins” and different symptoms, and this was one of the first articles that came up. I realize you are referencing “mold” and “fungal infections”….does this fall under the category of biotoxins? Or are they completely different?

  2. Thanks, Maarten! I like your chart, it is nice and compact, easy to keep up with. Do you have an Excel file, or some form I could use to give to our doctors? Many of our patients are not able to do quite as much active exercise as you are able to do, but the concept of keeping track is still the same. Have you seen Dr. Ritchie Shoemaker’s writing on the impact certain types of illness have on blood and oxygen circulation issues, thereby casuing trouble with exercise? He writes about it in Mold Warriors, and again in his newer book, Surviving Mold. He highly recommends keeping track of the response to exercise as a means of slowly increasing the body’s ability to make use of oxygen and possibly overcoming post exertional malaise. Sounds like you are working on it.
    Susan
    GMA Research Coordinator
    susan@gordonmedical.com

  3. Love your blog. I have a blog where i share a document I made for people to evaluate their chronic illness. Do you want to take a look at it? May be you can use it or share with others. Thanks. Maarten