Susan Friedl

post

New Study Finds Lyme Bacteria Survive a 28-day Course of Antibiotics When Treated Four Months After Infection by Tick Bite

Risk of Tick Bites in Tall Grass

Risk of Tick Bites in Tall Grass

All subjects treated with antibiotics were found to have some level of infection 7–12 months post treatment.

Despite testing negative by antibody tests for Lyme disease, two of 10 subjects were still infected with Lyme bacteria in heart and bladder.

Lyme bacteria which persist are still viable.

Portola Valley, California, Dec. 13, 2017 — Bay Area Lyme Foundation, a leading sponsor of Lyme disease research in the US, today announced results of two papers published in the peer-reviewed journals PLOS ONE (read full paper) and American Journal of Pathology (read full paper), that seem to support claims of lingering symptoms reported by many patients who have already received antibiotic treatment for the disease.

Based on a single, extensive study of Lyme disease designed by Tulane University researchers, the study employed multiple methods to evaluate the presence of Borrelia burgdorferi spirochetes, the bacteria that cause Lyme disease, before and after antibiotic treatment in primates. The study also measured the antibody immune response to the bacteria both pre- and post- treatment, as this is how current diagnostics typically evaluate Lyme disease in humans.

The data show that living B. burgdorferi spirochetes were found in ticks that fed upon the primates and in multiple organs after treatment with 28 days of oral doxycycline. The results also indicated that the immune response to the bacteria varied widely in both treated and untreated subjects.

“It is apparent from these data that B. burgdorferi bacteria, which have had time to adapt to their host, have the ability to escape immune recognition, tolerate the antibiotic doxycycline and invade vital organs such as the brain and heart,” said lead author Monica Embers, PhD, assistant professor of microbiology and immunology at Tulane University School of Medicine.

“In this study, we were able to observe the existence of microscopic disease and low numbers of bacteria, which would be difficult to see in humans but could possibly be the cause of the variable and nonspecific symptoms that are characteristic of post-treatment Lyme disease syndrome. Although current antibiotic regimens may cure most patients who are treated early, if the infection is allowed to progress, the 28-day treatment may be insufficient, based on these findings,” Embers said.

The findings also demonstrated:

  • All subjects treated with antibiotics were found to have some level of infection 7-12 months post treatment.
  • Despite testing negative by antibody tests for Lyme disease, two of 10 subjects were still infected with Lyme bacteria in heart and bladder.
  • Lyme bacteria which persist are still viable.

To better elucidate previous animal studies demonstrating that some B. burgdorferi bacteria survive antibiotics, the study explored Lyme disease infection in rhesus macaque primates treated with antibiotics and a control group who were also infected but not treated. This species has been shown to demonstrate a progression of Lyme disease most similar to humans, particularly related to erythema migrans, carditis, arthritis, and neuropathy of the peripheral and central nervous systems.

“Clearly, some medical practices governing diagnosis and treatment of Lyme disease should be reconsidered in light of this study. This study shows that we must reevaluate the current paradigm of antibody response tests for diagnosis and move away from the one size fits all approach to Lyme treatment,” said Wendy Adams, Research Grant Director, Bay Area Lyme Foundation. “Every day, patients with Lyme disease are told their symptoms cannot be caused by Lyme, because they test negative on antibody tests or because they have received a single course of antibiotics. More research and funding are imperative.”

In the study, ticks carrying B. burgdorferi spirochetes fed on ten primates. Four months post infection, half of the primates (five) received the antibiotic doxycycline orally for 28 days at a proportional dose to that used in human treatment. Five subjects were treated with placebo and all ten were evaluated by more than five different diagnostic methods to characterize any remaining infection. The researchers used several important techniques, including xenodiagnoses, to determine if the spirochete bacteria persisted.

The results show:

Few subjects displayed a rash. Although all subjects were infected, only one of the 10 displayed a rash with central clearing, the classical “bulls-eye” rash. The subject that developed this rash, interestingly, never mounted an immune response to five borrelia antigens throughout the study period, prior to and following treatment.

Organs may be infected even if antibody tests are negative. One subject which tested negative for B. burgdorferi by skin biopsy cultures, PCR and in vivo cultures, was found to have B. burgdorferi infecting the heart. Another untreated subject, who was ultimately shown to have residual Lyme bacteria in the bladder, showed a decrease in immune response over the course of infection, with a negative xenodiagnosis test in the late stage, which would signal that the animal self-cured.

Intact spirochetes were found in three of five treated and four of five untreated subjects based on xenodiagnosis results 12 months after the tick bite.

Immune responses to B. burgdorferi varied greatly post-treatment, with one subjects antibody levels dropping to pre-bite levels for three antigens while another subject experienced elevated antibodies for the same antigens throughout the study period. This is significant because it demonstrates that subjects infected with the same strain of B. burgdorferi may have different immune responses to the same antigen. And, because humans, like primates, are genetically diverse, it underscores that testing antibody responses may be inherently unreliable as a singular diagnostic modality for Lyme disease.

Widespread and variable microscopic disease was observed in all infected subjects, despite antibiotic treatment. Compared to uninfected subjects of the same age, infected subjects in this study (treated and untreated) demonstrated Inflammation in and around the heart, in skeletal muscles, joints, and the protective sheath that covers the brain, and near peripheral nerves.
Rare, but intact B. burgdorferi spirochetes were found in the tissues of both the treated and untreated subjects. In two subjects treated with doxycycline, multiple Lyme bacteria were observed in the brain tissue. Others organs in which the spirochetes were observed included the heart, joints, bladder, skeletal muscle and adjacent to peripheral nerves.

Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding

Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques

About Lyme disease
One of the most common infectious diseases in the country, Lyme disease is a potentially disabling infection caused by bacteria transmitted through the bite of an infected tick to people and pets. If caught early, most cases of Lyme disease can be effectively treated, but it is commonly misdiagnosed due to lack of awareness and unreliable diagnostic tests. There are about 329,000 new cases of Lyme disease each year, according to statistics released in 2015 by the CDC. As a result of the difficulty in diagnosing and treating Lyme disease, as many as one million Americans may be suffering from the impact of its debilitating long-term symptoms and complications, according to Bay Area Lyme Foundation estimates.

About Bay Area Lyme Foundation
Bay Area Lyme Foundation, a national organization committed to making Lyme disease easy to diagnose and simple to cure, is the leading public foundation sponsor of innovative Lyme disease research in the US. A 501c3 non-profit organization based in Silicon Valley, Bay Area Lyme collaborates with world-class scientists and institutions to accelerate medical breakthroughs for Lyme disease. It is also dedicated to providing reliable, fact-based information so that prevention and the importance of early treatment are common knowledge. A pivotal donation from The Laure L STEM Fund covers all overhead costs and allows for 100% of all donor contributions to Bay Area Lyme Foundation to go directly to research and prevention programs. For more information about Lyme disease or to get involved, visit www.bayarealyme.org or call us at 650-530-2439.

video

UNREST – Watch Free on PBS Website

 

15 great documentaries are in contention for an Oscar but only one was directed from bed. See how Jen Brea, with creativity, tenacity and tech, made the breakthrough doc UNREST.  Follow filmmaker Jennifer Brea’s struggle with Chronic Fatigue Syndrome and meet others coping with this often-devastating and little-understood condition in this intimate documentary.

Watch Free on PBS website.

Not in the US? Here are all the ways to watch: http://unrest.film/watch

#UnrestPBS #Spoonie

video

UNREST – Independent Film about CFS/ME Tonight on PBS – in the running for an Oscar!

 

15 great documentaries are in contention for an Oscar but only one was directed from bed. See how Jen Brea, with creativity, tenacity and tech, made the breakthrough doc UNREST *tonight*, Jan 8th, on PBS. http://www.pbs.org/independentlens/tv-schedule/#schedule-local

To watch locally in the San Francisco Bay Area:

Unrest

Follow filmmaker Jennifer Brea’s struggle with Chronic Fatigue Syndrome and meet others coping with this often-devastating and little-understood condition in this intimate documentary.

UPCOMING BROADCASTS:

  • KQED 9: Mon, Jan 8, 2018 — 10:00pm
  • KQED 9: Tue, Jan 9, 2018 — 4:00am
  • KQED World: Wed, Jan 10, 2018 — 5:30pm
  • KQED World: Thu, Jan 11, 2018 — 6:30am
  • KQED World: Thu, Jan 11, 2018 — 12:30pm
  • KQED World: Sat, Jan 13, 2018 — 9:00am

#UnrestPBS #Spoonie

image

Happy Holidays From GMA!

Happy Holidays GMA 2017
From all of us, to all of you! To those who made it through the year, we wish you joy and love and health in the new one. To those who have suffered losses, our hearts are with you. GMA will continue to do all that is possible to serve it’s patients and the larger community in 2018, hoping for recovery in body, home, and friends and family.

Salut! * Sláinte! * 乾杯! * Skål! * Proost! * நல் ஆரோக்கியம் பெருக * Saúde! * Cheers! * शुभमस्तु  * Santé! * Prost!  * གཟུགས་པོ་བདེ་ཐང་། *  Le’tenachin!  * Ahóá!  * Бу́дем здоро́вы!  * L’Chaim!

post

New Findings: Non-GMO Eaters Recover from Obesity, Anxiety, and Chronic Diseases

If you’ve been wondering if you really need to switch to non-GMO foods, a new peer-reviewed article may change your mind—and your life. View a powerful and informative video interview of Michelle Perro, MD, a top pediatrician who witnesses in her practice every day the same type of health improvements reported in the survey.

*The links mentioned in the video are listed below. You can also see them on this page, and sign up there to get advance notice about the new video that will be premiered soon, as well as the ebook offered. 

*Find out more about Michelle Perro, MD and her book “What’s Making Our Children Sick?” due out in January 2018.The book is available for pre-order now!

A new article, “Survey Reports Improved Health After Avoiding Genetically Modified Foods,” focuses on a survey conducted by the Institute for Responsible Technology (IRT) of more than 3250 people who switched to a largely non-GMO diet and reported improvements in 28 health conditions. An astonishing 85% of respondents reported improvements in their “digestive problems,” the ailment most commonly cited. Of these respondents, 80% said their digestive issues were “significantly improved”, “nearly gone”, or “completely recovered”.

Remarkably, at least half the respondents also reported recovery from fatigue, obesity, brain fog, food allergies, and anxiety or depression. Access the article with the complete list of conditions that improved.

What is it about GMOs that may be damaging our health? The article, peer-reviewed and published in the International Journal of Human Nutrition and Functional Medicine, lays out the known side effects, ranging from increased allergens and toxins in the food to high residues of Roundup® herbicide. (see more about the dangers of Roundup.) Most GMOs are designed to withstand heavy doses of Roundup, which, according to the World Health Organization, is a known carcinogen. Jeffrey M. Smith, the article’s author, cites evidence of many other serious health dangers of this popular herbicide as well as of GMOs.

Simply eating non-GMO isn’t always sufficient to protect your help, says Smith, since many non-GMO crops are also doused with Roundup just before harvest.

Find out how to protect yourself and your family. View either the easy-to-read summary or the scientific, peer-reviewed article itself.

Make sure to watch or record the Jeffrey Smith interview on The Doctors on Wednesday, October 8- we need high numbers to let the media networks know that glyphosate harm is a MAINSTREAM issue.

Notice courtesy of Moms across America

post

How to Manage Chronic Stress from Natural Disasters

Twig’s StressLess Series for Getting Through Wildfires and Other Natural Disasters

Twig on a respite following the firestorm around his homestead – 2014.

Now with the urgency of the fires somewhat behind us, we have to find ways to move to the next phase, to keep from becoming trapped in the stress cycle. As usual, one of our patients had a great resource, and sent us a link to this podcast series, from Anthony Twig Wheeler, a therapist who lived through the Washington fires in 2014. He produced a series of podcasts on how stress, especially chronic, long lasting stress, such as that from recovering from a major fire event, affects the body. He also gives a series of things you can do to interrupt the unnecessary stress response that we can get locked into. I posted it on our Facebook page a few days ago, but want to bring it up again so everyone gets a chance to take advantage.

The podcasts are free, each are only 5-25 minutes long, and are intended to be listened to over days, so that you can put into play each tip that he gives. I have been listening to them since we got the suggestion, and am finding them incredibly helpful. Some of the things about the stress response I knew, some I was not aware of. Either way, the simple, practical, often physical actions to take have been deeply helpful for me, and I want to be sure everyone has a chance to use them. I find just playing one of the talks when I get stressed helps remind me to let go, and actually doing what he suggests takes it even further. If you find they help you, let Twig know. [Read more…]

status

Nebulized Glutathione offered at GMA for smoke irritation

Nebulizer treatmentsDue to the fires and amount of toxic smoke this past week, many people are finding that the smoke has caused lung irritation, chest constriction, asthma, coughing or wheezing. GMA is offering nebulized glutathione, a powerful antioxidant which acts as a powerful antioxidant and detoxifier for the lungs, protecting the whole respiratory tract from oxidative stress. Because many pulmonary diseases and respiratory related conditions are affected by deficient antioxidant status, poor oxygenation and/or impaired host defenses, glutathione is an excellent choice to support healthy lung function. Oral or IV glutathione will not be as effective for treating lungs as the nebulized glutathione.

With a nebulizer, glutathione is delivered as a fine mist into the upper respiratory tract and lungs through a mask that covers the nose and mouth or delivered directly into the lungs with a mouth piece. Each nebulizer treatment takes between 15-25 minutes.

In terms of side effects, glutathione is very safe. Some people will experience mild coughing and a unpleasant sulfur odor. However, for those who are sulfite sensitive, glutathione is contraindicated. If you aren’t sure if you are sulfite sensitive, sulfite strips can measure your urine. Those who test positive for sulfites should not use glutathione. Call the office at (707) 575-5180 to set up treatment. Phones are now open again and staff is on hand.

status

Check Our Facebook Page for Updates on Fire Conditions.

Santa Rosa on Fire - Carla Rae Lukens October 2017

Santa Rosa on Fire – Carla Rae Lukens October 2017

GMA Offices are Open as of 10/16/17

GMA has been dealing with fire issues from the tragic complex fire we are living with in Northern California, both personally and as a business. During this period, we request that you use our GMA Facebook page to stay updated on what will be happening and what will be available at GMA. We will be posting updates about GMA, but also info on the ongoing emergency, medical issues, and other details on the long term recovery that will be required after these fires. There are already numerous links listed to agencies that you will find essential if you are living in the fire emergency area. [Read more…]

status

Gordon Medical closed Monday due to fires in Santa Rosa

Because staff all lives in the area of the fires and have been evacuated, both the Santa Rosa and Marin offices will be closed until further notice. We will let you know when we are open again.

status

Free Shipping on NPScript through October

np-script-logo

For a limited time, through October 31st, GMA patients can receive FREE ECONOMY SHIPPING on their NPScript orders. No minimum order required.

Shop the full catalog of thousands of products, including supplements, personal care products, even products for your animal’s health, 24 hours a day. Professional quality, only available to patients of Gordon Medical. If you have not yet signed up for your account, most patients will already have their email addresses uploaded to NPScript. To create an account, enter your email address at the sign in page, and enter “Forgot Password.” you will be sent information on how to create your password.

Wondering what to order? The staff at GMA really likes Heritage fragrance free colloidal silver foaming soap, for patients who want to boost the toolbox for the upcoming cold and flu season. It lasts a long time, and doesn’t dry out our hands like other soaps or conventional hand sanitizers. The addition of colloidal silver helps to improve our chances of staying healthy this winter!

Heritage Foaming Colloidal Silver You are going to love our new moisturizing liquid hand soap with all the benefits of colloidal silver! Luscious emollient-based soap foams onto your hands for instant coverage with a simple pump action. Rich olive and coconut cleansers blend with vegetable glycerin, castor oil, and colloidal silver to assure potent cleaning power that is good for your skin. Choose from delightfully uplifting essential oils of rosemary and spearmint or natural unscented.

Formulated with moisturizing olive (castil-based) and coconut derived cleansers, plus castor oil and vegetable glycerin, and all the benefits of colloidal silver for optimal cleaning power. Hypoallergenic fragrance free. These pure ingredients support healthy skin and will leave your skin soft and clean with no soapy residue.

*Certified Organic
Sulfate Free
Gluten Free
Paraben Free