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AIMS Surveys Now Going Out in Batches

Genes are ancestor based. Metabolites are how you are doing now.

Science in Service of HumanityIf you are curious to be updated on our research please check the Research News section on the SISOH website. This is the most up to date information. You can subscribe to the Sisoh blog by inputting your email in the subscription box on the sidebar.

We are sending out the Analyzing Individual Metabolomics Study (AIMS) survey emails in small batches. If you have signed up online or spoken to research coordinator Asha Baxter you are on the list for AIMS. Please be patient. *If you have a gmail account please check your spam or promotions email for our email.

Completion of the survey will add you to our list of potential study participants. Once we have enough participants for your age group, you will be given instructions on how to formally enroll in the study. All study participants will receive study updates and overall study results. Additionally, a metabolomic report of personal metabolomic results will be sent to a participant’s physician.

Please Donate to help us find answers to Chronic Illness. Every dollar counts. Donations to our non-profit GMRC are tax-deductible.

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Health Rising – Recovery Potentially Possible: Naviaux Talks on Chronic Fatigue Syndrome (ME/CFS)

Health Rising
 
 
by Cort Johnson | Dec 13, 2016
 

Personalized treatment plans will require addressing the core metabolic abnormalities found in most ME/CFS patients plus the individual metabolic issues found of each patient.

Treatments that work for a time and then stop could be the result of not addressing all the metabolic needs of an individual.

Cort Johnson – “Recovery Potentially Possible: Naviaux Talks on Chronic Fatigue Syndrome (ME/CFS)”

The day after my brother’s wedding I shot down to San Diego to meet Rachel Riggs and a doctor with ME/CFS. Rachel, who has turned into a volunteer patient coordinator had enrolled me in Naviaux’s next metabolomics study. (Resistance, I quickly surmised, was futile – not that I was putting up any.) Rachel chatted away on the phone with another potential participant as we drove down to Naviaux’s lab. I was one of the last to give blood. editor’s note: Cort actualy enrolled in the 2nd Metabolomics study. SISOH is now recruiting for a 3rd study.

After I gave a surprising small amount of blood we tromped down the hall to meet with Dr. Naviaux in his workroom, the industrial looking pipes overhead bringing back memories of college labs in the past. Ducking into one lab Rachel showed me two $500,000 dollar mass spectometer machines each the size of a large microwave.

Gracious, as always, Dr. Naviaux offered us some coffee or tea. A bit spacey from my fast I tried out some green tea – at which point my nose immediately stopped up. At the first sound of my sniffles Naviaux turned to me and said we would have to note that for the study. (No one with a cold is allowed in the study.) Those sniffles cleared up later. (Dr. Naviaux, if you read this I promise it was from the tea…)

Read More

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More from Dr. Naviaux on metabolics and Chronic Fatigue Syndrome

Science in Service of HumanityDr. Naviaux has responded to some comments on the groundbreaking paper, “Metabolic Features of Chronic Fatigue Syndrome”.

In this response he addresses the need for metabolic studies in other disease groups, whether metabolic studies determine the initial cause of sysmptoms, and how dauer states relate to what is seen in CFS.

We thank Vogt et al. for their comments (1). We respond to their three points in order. First, we are aware of the need to extend future metabolomics studies to include other disease groups. We stated this fact in the discussion of ref. 2 and are validating the results in independent cohorts. The detailed biochemical phenotype or signature that we found provides a first glimpse at a previously hidden biology. For example, disturbances in sphingolipid metabolism have important implications for immunobiology and neuroendocrine regulation relevant to myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) (3). Sphingolipids are important mediators of the cell danger response (CDR) (4), and the CDR is an important regulator of the behavioral and functional changes produced by infection, and associated with sickness behavior (5). The biochemical phenotype of ME/CFS is distinct from other diseases that Vogt et al. (1) named. For example, in heart failure, metabolomics shows that long chain acyl-carnitines are increased (6), but these long chain acyl-carnitines were not changed in ME/CFS (2). In our view, chemistry and metabolism underlie all aspects of human biology. Our studies show that metabolomics can be used as a new lens to reveal unexpected biology that was invisible before…

Robert Naviaux, et all

Read full response.
Read the letter the response was based on.

PARTICIPATE in metabolomics research at SISOH.

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Support CFS/ME Research by Shopping at AmazonSmile

Now you can support Gordon Medical’s research into CFS/ME and other chronic illness by shopping at AmazonSmile. Just use the link here in the post and your purchases will help support Gordon Medical Research Center’s fundraising efforts. For eligible purchases at AmazonSmile, the AmazonSmile Foundation will donate 0.5% of the purchase price to the customer’s selected charitable organization. AmazonSmile is the same Amazon you know. Same products, same prices, same service.

We hope you select us!

 
We are currently fundraising for the Analyzing Individual Metabolomics Study (AIMS), our third research study on the use of metabolomics in CFS/ME. Our first study resulted in the ground breaking research, “Metabolic features of chronic fatigue syndrome,” published in the Proceedings of the National Academy of Sciences. Our second study, a replication study with a larger group of CFS patients, has completed enrollment, and is processing the data collected. Our thirds study, AIMS, is now recruiting participants and fundraising. We will be looking at how comprehensive metabolomics analysis can be used to evaluate CFS/ME. AIMS builds on our previous studies, which have demonstrated there is a clear metabolomic profile in patients with CFS/ME. The more funds we are able to raise, the more participants we can include in this important research. To find out more about our research, or to sign up to participate, go to our research website at Science in Service of Humanity (SISOH). You can also make a tax deductible donation directly to the Gordon Medical Research Center.

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The Most Important and Groundbreaking Study of ME/CFS to Date

 in Clinical Pain Advisor
September 27, 2016

Metabolomic Deficiencies Characteristic of Chronic Fatigue Syndrome

In a study designed to test the utility of targeted metabolomics in the diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), researchers identified a unique chemical signature that differentiates affected patients from healthy individuals.

Ronald W. Davis, PhD, director of Stanford Chronic Fatigue Syndrome Research Center of Stanford University School of Medicine commented on the findings of Dr. Naviaux’s group on the the Open Medicine Foundation website, where he serves as director of the Scientific Advisory Board.

“It is the most important and groundbreaking study of ME/CFS to date. Extending recent indications of metabolic alterations in ME/CFS, this study provides the first comprehensive, quantitative demonstration of the metabolomic deficiencies that characterize the disease.”

Read More

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Press Democrat: Santa Rosa doctor’s study offers new insight into chronic fatigue syndrome

GUY KOVNER
THE PRESS DEMOCRAT | September 21, 2016

Eric Gordon MDA new study initiated by (Eric) Gordon and including Harrison as one of the subjects could provide that breakthrough.

The study, published last month, detected a “chemical signature” in the blood of chronic fatigue syndrome patients, establishing for the first time that chronic fatigue syndrome is an “objective metabolic disorder,” said co-author Dr. Robert Naviaux, the UC San Diego researcher who identified the blood chemical anomalies associated with the condition.

Gordon is a co-author of the study, and most of the patients in the study came from his practice.

Read PD Article

Read Full Study Paper

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Gordon Medical Research Center is organizing a new community sponsored research study to investigate how individual metabolomic data can be used to evaluate CFS/ME.

GMRC logo paddedThis will be the third study organized by GMRC researching how comprehensive metabolomic analysis can be used to evaluate CFS/ME. This study follows our first study, recently published in the Proceedings of the National Academy of Science, which demonstrated there is a clear metabolomic profile in patients with CFS/ME; and our second North American based CFS/ME study, which has finished enrolling patients and will be completed soon. (see more about Metabolomics research)

Evidence that CFS truly does deserve all three elements of its name has accumulated over the years but a definitive diagnostic test has remained elusive. Until, perhaps, now. For in this week’s Proceedings of the National Academy of Sciences Robert Naviaux of the University of California, San Diego, and his colleagues published evidence that the metabolisms of those diagnosed with CFS are all changing in the same way. Their data suggest it is this cellular response to CFS-triggering traumas, and not the way the response is set in motion, which should define the illness. They also show that this response produces a chemical signal that might be used for diagnosis.

The Economist

This third study will be the first to look at how individual as opposed to population based metabolomics data can be used to evaluate CFS/ME. GMRC’s third CFS/ME research study will be a community-sponsored investigation. The CFS/ME community is a highly motivated group and we will need their support to accomplish our goal of understanding how personal metabolomic data can be used to evaluate CFS/ME.

Members of the CFS/ME community and their advocates can contribute to the success of the study in three main ways:

  1. They can participate in the study by volunteering a blood sample. – PARTICIPATE
  2. They can recruit a person without a diagnosis of CFS/ME to donate a blood sample that will serve as a comparison sample.
  3. Members of the community can make a tax-deductible donation to fund the study. – DONATE

All donations are welcome, and donations to this third metabolomic study will go to sample collection, metabolomic data generation, and development of CFS/ME-specific analysis software.

For a donation of $1500 or more, individuals will receive a personal metabolomic report that will show them how their personal metabolomic profile compares to a healthy population and the overall CFS population. Included in the >500 metabolites in this report will be analysis of sphingomyelin metabolites which were shown to be of interest to the CFS/ME community in our first study. This is the ONLY metabolomic report currently capable of providing data on this critical class of molecules.

DONATE NOW!

We look forwarded to working with the CFS/ME patient community and their supporters to make this unique community-sponsored research study a success.

 

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Washington Post: Chronic fatigue syndrome may be a human version of ‘hibernation’

Gordon Medical Research CenterBy Ariana Eunjung Cha September 6, 2016

A new study raises the extraordinary possibility that humans may be able to put themselves into a kind of hibernation state as well — but in a way that hurts us rather than helps us.

The research, published recently in the Proceedings of the National Academy of Sciences, focuses on the devastating condition known as myalgic encephalomyelitis, more popularly known as chronic fatigue syndrome. CFS is one of the biggest mysteries of modern medicine and is characterized by severe fatigue and related issues such as headaches and memory problems. According to conservative estimates, 2.5 million people in the United States suffer from it, but no cause has ever been pinpointed. That has made some doctors so skeptical of the diagnosis that many patients complain that they have sought help, only to be told the symptoms are in their heads.

Read more…

DONATE TO CFS RESEARCH

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The Telegraph News: Scientists find signature of Chronic Fatigue Syndrome in blood which suggests disease is the body going into hibernation

Gordon Medical Research CenterBy Telegraph Reporters
2016-08-30

New research has revealed a chemical signature of the disease in the blood of those with ME. Scientists from the University of California claim it is similar to a state found in nematode worms called dauer, where the metabolism adjusts to a difficult environment by slowing down.

This hibernation state enables existence, but not much more.

Read more…

DONATE TO CFS RESEARCH

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ME Action says: NAVIAUX’S METABOLISM PAPER IS ABOUT AS BIG AS YOU THINK

Gordon Medical Research CenterFor those who are wondering at the results and their implications, Naviaux’s study in a nutshell states that the cells of ME patients are in a sort of protective hibernation, limiting their consumption of resources and engaging in a hypometabolic state as a response to infection or other stressors. By examining patients’ metabolites in detail, it was found that this degree of protective hibernation correlates directly to clinical severity.

Naviaux also posits that cells in ME/CFS are cells under enormous stress, for which they create a series of defenses, metaphorically installing a superior lock and alarm system and hiding all the valuables. However, some pathogens know the code to get in, and when the resources are hidden, the host can’t use them, either. Both of these aspects of this mode of cellular defense have profound implications for symptomology.

Read more…

DONATE TO CFS RESEARCH