The collaboration of an innovative medical practice with a university research center has been my lifelong dream. Combining forces with Dr. Robert Naviaux and his research into metabolomics, mitochondrial function, and chronic inflammatory disease is now bringing this dream to life.
The opening of the Gordon Medical Research Center is a critical element in developing funding for the research into the complex illnesses we focus on. Your donation will make possible further research into metabolomics and mitochondrial function and their impact on health and illness. Illnesses potentially caused by mitochondrial dysfunction will ultimately affect over 50% of the people born today. These diseases include autoimmune diseases, autism, Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS), Post-Traumatic Stress Disorder (PTSD), Gulf War Illness, diabetes, heart disease, certain mental health disorders, and cancer.
Eric Gordon, MD
Founder, Gordon Medical Associates
Science in Service of Humanity
Gordon Medical Research Center
Funding Research For Poorly Defined and Undiagnosed Chronic Illness
Dr. Robert Naviaux and I have submitted for publication a study, now under peer review and expected to be published in the fall of 2016, looking at 450 metabolites in 43 people with CFIDS/ME and 43 age and sex matched controls. We found a characteristic chemical signature differentiating the patients from the controls. We just received a grant, that along with donations to our newly established non-profit, will allow us to replicate this study. If our findings are indeed replicated we will have a biochemical test for CFIDS/ME. This will help the suffering of the who knows how many patients with CFIDS/ME who lose their friends and families because they don’t look sick and have normal blood tests. It will also allow more directed research to the treatment of this illness.
The applicability to Lyme is that CFIDS/ME is a wastebasket diagnosis. It is the most common end state of many chronic inflammatory diseases. Chronic Lyme and Tick Borne Diseases that don’t respond to antibiotic therapy are in this class of illnesses. Many of the CFIDS/ME patients have Lyme in their history. Most of the chronic Lyme or “post Lyme” patients fit the criteria for CFIDS/ME.
Our plan is to start enrolling Gordon Medical patients this Fall in a “post Lyme” metabolomic study. This study will biochemically define chronic Lyme disease and if large enough, allow us to define subgroups of these patients. Some day soon, I envision us able to use the groupings to predict appropriate treatment regimes. At the current time I have good track record in treating treatment resistant chronic Lyme patients who can afford to stay near my clinic for long periods of time and try multiple therapies. This is wasteful of resources and stressful to the patient. It also limits treatment to the wealthy. Currently it is the best we can do, but we need to do much better.
Metabolomics is the quantification of the small to medium sized molecules that the body uses for fuel and communication. These chemicals are the ones that control the production of energy and maintenance of cells and organs. They also give us insight into the functions of the mitochondria, the organelles that are known as the “powerhouse of the cell”.
Dr Naviaux has written articles showing that the mitochondria also are at the heart of the bodies immune response.. He named this The Cell Danger Response. Toxins and infections are some of the main danger signals that mitochondria respond to. When that signal persists, chronic inflammatory disease often ensues. Dr Naviaux has some exciting experimental work showing we can “unstick” the persistent Cell danger Response and allow the immune system to stand down.
Dr Naviaux is an expert in genetics , inborn errors of metabolism , and mitochondrial diseases. He is now concentrating on metabolomics and mitochondrial response to inflammation. He has first hand research experience with the limitations of genetics in understanding complex diseases in adults. The first clinical study on treatment of autism using his concept is now complete, and the results are very promising.
If you or someone you know would like to participate in our research on Metabolomics, would like to be a study participant, would like to be a healthy control subject, would like to have the Metabolomics test run on yourself, or are interested in donating to the GMRC research, please contact us for more information.
Please look over the Gordon Medical Research Center website, and donate if you can. All sizes of donations are gladly accepted, and are tax deductible. Money over the initial $400,000 will go toward improvements in the testing process and in the data analysis process. Thank you!