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AIMS Surveys Now Going Out in Batches

Genes are ancestor based. Metabolites are how you are doing now.

Science in Service of HumanityIf you are curious to be updated on our research please check the Research News section on the SISOH website. This is the most up to date information. You can subscribe to the Sisoh blog by inputting your email in the subscription box on the sidebar.

We are sending out the Analyzing Individual Metabolomics Study (AIMS) survey emails in small batches. If you have signed up online or spoken to research coordinator Asha Baxter you are on the list for AIMS. Please be patient. *If you have a gmail account please check your spam or promotions email for our email.

Completion of the survey will add you to our list of potential study participants. Once we have enough participants for your age group, you will be given instructions on how to formally enroll in the study. All study participants will receive study updates and overall study results. Additionally, a metabolomic report of personal metabolomic results will be sent to a participant’s physician.

Please Donate to help us find answers to Chronic Illness. Every dollar counts. Donations to our non-profit GMRC are tax-deductible.

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Watch for AIMS Survey Going Out to Participants

Science in Service of HumanityThe first round of surveys for participants in the Analyzing Individual Metabolomics Study (AIMS) went out yesterday. Due to a glitch in the software that didn’t produce the necessary IDs for the participants, it is being resent. Keep an eye on your inbox if you have signed up for the study. [Read more…]

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The Most Important and Groundbreaking Study of ME/CFS to Date

 in Clinical Pain Advisor
September 27, 2016

Metabolomic Deficiencies Characteristic of Chronic Fatigue Syndrome

In a study designed to test the utility of targeted metabolomics in the diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), researchers identified a unique chemical signature that differentiates affected patients from healthy individuals.

Ronald W. Davis, PhD, director of Stanford Chronic Fatigue Syndrome Research Center of Stanford University School of Medicine commented on the findings of Dr. Naviaux’s group on the the Open Medicine Foundation website, where he serves as director of the Scientific Advisory Board.

“It is the most important and groundbreaking study of ME/CFS to date. Extending recent indications of metabolic alterations in ME/CFS, this study provides the first comprehensive, quantitative demonstration of the metabolomic deficiencies that characterize the disease.”

Read More

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Gordon Medical Research Center is organizing a new community sponsored research study to investigate how individual metabolomic data can be used to evaluate CFS/ME.

GMRC logo paddedThis will be the third study organized by GMRC researching how comprehensive metabolomic analysis can be used to evaluate CFS/ME. This study follows our first study, recently published in the Proceedings of the National Academy of Science, which demonstrated there is a clear metabolomic profile in patients with CFS/ME; and our second North American based CFS/ME study, which has finished enrolling patients and will be completed soon. (see more about Metabolomics research)

Evidence that CFS truly does deserve all three elements of its name has accumulated over the years but a definitive diagnostic test has remained elusive. Until, perhaps, now. For in this week’s Proceedings of the National Academy of Sciences Robert Naviaux of the University of California, San Diego, and his colleagues published evidence that the metabolisms of those diagnosed with CFS are all changing in the same way. Their data suggest it is this cellular response to CFS-triggering traumas, and not the way the response is set in motion, which should define the illness. They also show that this response produces a chemical signal that might be used for diagnosis.

The Economist

This third study will be the first to look at how individual as opposed to population based metabolomics data can be used to evaluate CFS/ME. GMRC’s third CFS/ME research study will be a community-sponsored investigation. The CFS/ME community is a highly motivated group and we will need their support to accomplish our goal of understanding how personal metabolomic data can be used to evaluate CFS/ME.

Members of the CFS/ME community and their advocates can contribute to the success of the study in three main ways:

  1. They can participate in the study by volunteering a blood sample. – PARTICIPATE
  2. They can recruit a person without a diagnosis of CFS/ME to donate a blood sample that will serve as a comparison sample.
  3. Members of the community can make a tax-deductible donation to fund the study. – DONATE

All donations are welcome, and donations to this third metabolomic study will go to sample collection, metabolomic data generation, and development of CFS/ME-specific analysis software.

For a donation of $1500 or more, individuals will receive a personal metabolomic report that will show them how their personal metabolomic profile compares to a healthy population and the overall CFS population. Included in the >500 metabolites in this report will be analysis of sphingomyelin metabolites which were shown to be of interest to the CFS/ME community in our first study. This is the ONLY metabolomic report currently capable of providing data on this critical class of molecules.

DONATE NOW!

We look forwarded to working with the CFS/ME patient community and their supporters to make this unique community-sponsored research study a success.

 

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New Study Published: Metabolic features of chronic fatigue syndrome

Robert NaviauxMetabolic features of chronic fatigue syndrome. Naviaux RK, Naviaux JC, Li K, Bright AT, Alaynick WA, Wang L, Baxter A, Nathan N, Anderson W, Gordon E. Proc Natl Acad Sci U S A. 2016 Aug 29.

Download a PDF copy – Metabolic features of chronic fatigue syndrome

The Metabolomics study done in collaboration with Robert Naviaux of the Naviaux Lab and Gordon Medical Associates is now available!

Here we report a metabolomics study of Chronic Fatigue Syndrome (CFS) in 45 CFS patients and 39 controls. Our data show that despite the heterogeneity of factors leading to CFS, the cellular metabolic response in patients was homogeneous, statistically robust, and chemically similar to the evolutionarily conserved persistence response to environmental stress known as dauer.

Read full paper…

Some people still argue that CFS is not a real illness but all in the mind. Does your discovery of a chemical signature help shatter this myth?

Yes. The chemical signature that we discovered is evidence that CFS is an objective metabolic disorder that affects mitochondrial energy metabolism, immune function, GI function, the microbiome, the autonomic nervous system, neuroendocrine, and other brain functions. These 7 systems are all connected in a network that is in constant communication. While it is true that you cannot change one of these 7 systems without producing compensatory changes in the others, it is the language of chemistry and metabolism that interconnects them all.

Metabolomics Q&A for CFS v6 

Support further research at the Gordon Medical Research Center

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New Study Shows Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome

A new study recently published in PLOS One shows that neuromuscular strain (utilizing straight leg raises) significantly increases body pain and cognition difficulties compared to healthy controls and CFS patients who did not do the leg raises. For the following 24 hours, the CFS group who did the leg raises showed increased composite scores in fatigue, body pain, lightheadedness, concentration difficulties, and headache.

While not something new to those with CFS/ME, it is another piece of support for the reality of the illness. [Read more…]