Update on the Methylation Protocol

What Is the Methylation Protocol?

Gordon Medical is returning to the original protocol methylation protocol, which includes B12 Perque Activated Lozenges and FolaPro, along with the other items we have always used. These 2 items were replaced by liquid drops for some time (B12 Hydroxy Mega Drops & MethylMate B drops), but due to some allergic reactions in some of our patients, we are returning to the original tablets.


  • If you are on the methylation protocol, before making any changes, please be sure to consult your physician.
  • Patients on the drops who are doing fine can continue the drops, or can switch back to the tablets.
  • All patients new to the protocol should do the tablets.


METHYLATION PROTOCOL –  Adapted from a treatment program developed by Amy Yasko, N.D., Ph.D.

***Updated August 2012 (returned to original protocol of tablets, from oral drops)***

  1.  FolaPro:
    •  60 tabs –  Metagenics — can only be purchased from a  health care practitioner
    •  1/4 tablet (200 mcg total)
  2.   Perque Activated B12: 
    • 100 tablets –  Metagenics — can only be purchased from a  health care practitioner
    •  1 sublingual lozenge daily (2,000 mcg)
  3.  ActiFolate:
    •   60 tabs  Metagenics — can only be purchased from a  health care practitioner
    •  ¼ tablet (200 mcg) daily
  4.  General Vitamin Neurological Health Formula:
    •   180 tabs  – Holistic Health
    •  Start with ¼ tablet and increase dosage as tolerated to 2 tablets daily
  5.  Phosphatidyl Serine Matrix:
    •   60 softgels  Source Naturals
    • 1 soft gel capsule daily  (1 softgel = 500mg)

These supplements can be taken any time of day, with or without food. 

GO SLOWLY.  Occasionally, as the methylation cycle blockages are released, toxins are released and processed by the body, and this can lead to an exacerbation of symptoms. IF THIS HAPPENS, try smaller doses, every other day.  SLOWLY work up to the full dosages.  If you have questions, please call your provider to discuss them.

Occasionally these supplements can make patients sleepy, so some take them at bedtime. It may not be necessary to take partial tablets.  Many patients can tolerate full tablet doses.  Check with your practitioner.  (If you do need an effective pill cutter, one option is available at your local hardware stores; they are called “end cutting hobby pliers” and sell for about $10.)

Updated AUGUST 2012